Fumaric acid is generally employed as an acidulant and flavouring agent in liquid medicinal formulations. Although this usage is restricted due to the compound's exceedingly poor solubility in water, fumaric acid may be used as the acid component of effervescent tablet formulations. Additionally, it is a chelating agent that, when combined with other real antioxidants, demonstrates synergistic effects. Fumaric acid was employed to facilitate spheronization in the creation of innovative pelletized formulations produced by extrusion-spheronization, favouring the formation of fine pellets. It has also been researched as a potential replacement for lactose as a filler in pellets.
Both Fumaric Acid and its copolymer with sebacic acid have been studied as potential lubricants for effervescent tablets and as potential bioadhesive microspheres. It has been utilised as an acidifying agent and to enhance medication solubility in film-coated pellet formulations. In addition, fumaric acid is used as a food ingredient in quantities up to 3600 parts per million and as a medication to treat psoriasis and other skin conditions.
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