Theodor Escherich, an Austrian paediatrician, noticed a particular bacteria in the intestinal flora of children with diarrheal disease and children who were healthy. This discovery provided the first scientific proof that microorganisms are a normal component of the human body. The Veillonella parvula species, a bacterial member of the oral, digestive, urinary, and upper respiratory flora, and bifidobacteria, members of the intestinal flora, were among the other microorganisms isolated from the human body that were described by scientists in the years that followed.
Other microorganisms that belong to the human microbiome were identified throughout the 20th century after being isolated from the skin, gastrointestinal tract, urogenital tract, nasal passages, and oral cavities.
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