The use of active biological agents, such as plant-derived active biomolecules with antioxidant, antibacterial, or anti-inflammatory properties, may be used in biologic wound healing therapies, which aim to aid the restoration of the body's natural repair mechanisms. Wound Care Biologics dressings stop contamination, heat loss, protein and electrolyte loss, and evaporative water loss. They also promote the development of a granular wound bed and autolytic debridement. Tissue engineering, stem cell therapies, epidermal growth agents, and biological skin analogs may also be used.
A number of intracellular, extracellular, and intercellular processes, including collagen coagulation and deposition, epithelialization, fibrous tissue accretion, wound contraction, inflammatory events, tissue granulation, and remodeling, are coordinated and activated during the complex process of wound healing. Bioengineered products called wound care biologics are used to treat non-healing lower extremity wounds.
