Guidelines published by the National Institute for Health and Care Excellence (NICE) indicate routine magnetic resonance imaging (MRI) follow-up be done at intervals of 3 to 6 months for the first two years, 6 to 12 months for the next five years, and then annually after that (NICE 2018). These routine monitoring scans can detect GBM progression or recurrence, or they can identify it when new symptoms start to appear (Thompson 2019). However, in the first few months following initial Recurrent Glioblastoma Multiforme Treatment, it may be challenging to diagnose GBM progression or recurrence because of the possibility that its MRI appearance may be indistinguishable from pseudoprogression.
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