Rabies Vaccine are highly effective, but they are also among the most reactogenic. Redundant rabies vaccination exposes dogs to excipients and other chemicals unrelated to vaccine antigens, raising the unnecessary risk of adverse effects. Despite the "gross under-reporting of vaccine-associated adverse events" cited in the 2007 World Small Animal Veterinary Association (WSAVA) Vaccine Guidelines, research has shown that potent adjuvanted, killed rabies vaccines elicit the most frequent and severe adverse reactions in animals, emphasizing the importance of vaccinating only as needed to confer or maintain disease immunity.
Veterinary practitioners and animal owners are increasingly concerned about how to balance the need to protect animals and the people from rabies while lowering the risk of major side events associated with Rabies Vaccine. Live rabies virus challenge studies demonstrating the long-term duration of immunity of rabies vaccines beyond 3 years serve the dual purpose of protecting companion animals and the general public from rabies while avoiding redundant vaccination and lowering the risk of adverse events associated with vaccine adjuvants, antigens, and excipients.
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