The narrow nasal valve and complex convoluted nasal geometry, combined with dynamic cyclic physiological changes, provide efficient filtration and conditioning of inspired air, improve olfaction, and optimise gas exchange and fluid retention during exhalation. However, the potential barriers that these functional features impose on effective Nasal Drug Delivery Systems are frequently overlooked. With this context in mind, the benefits and limitations of existing and emerging nasal delivery devices and dispersion technologies are discussed, with a focus on clinical performance. The FDA guidance for nasal spray pumps and pressurised aerosols (pressurised metered-dose inhalers) with local action discusses the role and limitations of in vitro testing.
Read More- https://cmiblogdailydose.blogspot.com/2022/09/nasal-drug-delivery-systems-help-in.html
