How Are Single-Use Bioreactors Used for Cell Culture?

Large volumes of cells are cultured in single-use bioreactor. In contrast to conventional stainless steel multi-use systems, culture is carried out in and then discarded of a plastic bag. Turnaround time between production batches can be significantly shortened by skipping the cleaning and sterilisation procedures required with multi-use equipment. The culture bags are typically delivered sterile and prepared for use once they have been installed in the bag holder. Through the attached tubings, connections are made to the gassing and feed lines. Through the use of process analytical technologies, processes can be monitored and controlled using sensor ports or integrated single-use sensors (PAT).

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