Pharmacogenomics is also being used to develop new drugs that are tailored to specific genetic profiles. For example, the drug Ivacaftor was developed to treat cystic fibrosis, a genetic disorder that affects the respiratory and digestive systems. Ivacaftor works by increasing the activity of a protein called cystic fibrosis transmembrane conductance regulator (CFTR), which is mutated in patients with cystic fibrosis. Ivacaftor is effective only in patients with specific genetic mutations, highlighting the importance of pharmacogenomics in drug development.
Pharmacogenomics can also help to identify the risk of adverse drug reactions in certain patient populations. For example, the drug abacavir is used to treat HIV, but it can cause a severe hypersensitivity reaction in some patients. A genetic variation in the HLA-B gene has been identified as a risk factor for this reaction, and pharmacogenomic testing can help to identify patients who are at risk.
Discover More- https://cmiblogdailydose.blogspot.com/2023/04/pharmacogenomics-can-be-used-for.html
