The Q-TOF-MS is a "hybrid" instrument that combines time-of-flight mass spectrometry and quadrupole technologies. Although a time-of-flight tube has been used in place of the third quadrupole, the Q-TOF Mass Spectrometer instrumentation is very similar to that of a triple-quadrupole mass spectrometer. The first quadrupole (Q1) can be used as a mass filter to select particular ions based on their mass-to-charge ratio (m/z), or it can be used in radio frequency (RF) only mode to transmit all ions.
When neutral gas molecules like nitrogen or argon bombard ions in the second quadrupole (Q2), the result is a process known as collision-induced dissociation, which fragments the ions (CID). The Q2 is also capable of operating in RF-only mode without ion fragmentation. Ions are reaccelerated after leaving the quadrupole and enter the time-of-flight analyser's ion modulator region where they are pulsed by an electric field and accelerated orthogonally to their initial direction.
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