The adverse effects of Methotrexate Drugs can be extremely significant and even fatal. Methotrexate should only be used to treat cancer and a few other extremely serious illnesses that are resistant to conventional treatments. The dangers of taking methotrexate for your disease should be discussed with your doctor. Inform your doctor if you have renal disease or have previously had it, as well as if you have or have ever had excess fluid in your stomach area, the area around your lungs, or both. Additionally, let your doctor know whether you're using NSAIDs like aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), or salsalate. These ailments and prescription drugs may make you more likely to experience severe methotrexate side effects.
