Endometrial Rejuvenation
EndometrialRejuvenation
Endometrial Rejuvenation a solution for
Womenwho struggle to become pregnant because of poor endometrial thickness, can nowconceive naturally and give birth.
Whatis Endometrial Regeneration?
Pregnancyrequires not just a healthy embryo, but also a healthy and mature endometrium,which ensures the implantation of the embryo and the onset of yourlong-awaited pregnancy. if the endometrium isn't thick enough, the embryowill simply not be able to attach to the wall of the uterus.
EndometrialRejuvenation is the process to enhance quality of Endometrium forsuccessful implantation of embryo by improving the endometrial thickness& blood supply which helps embryos for implantation giving them propernutrition & hormones.
Themembrane lining the uterus is called the endometrium, the endometrium thickensduring the menstrual cycle in preparation for the implantation of an embryo. If theimplantation has not occured the membrane is shed, Shedding andregenerating its functional layer once every cycle is the unique capacityof the healthy endometrium , which is regulated by the hormones,progenitor cell populations and inflammatory mediators. The functions ofthe endometrium are to make optimal conditions for implantation of anembryo within the uterus. However, if any of those factors are perturbed,the result will be endometrial disorders with intrauterine scarformation, dysregulated proliferation and heavy menstrual bleeding.Without a healthy endometrium, pregnancy is impossible.
Thecondition of the endometrium determines the likelihood of a successfulpregnancy. If the endometrium is not thick enough, the embryo will simplynot be able to attach to the wall of the uterus thus it plays an importantrole in successful pregnancy. The minimal endometrial thickness requiredfor embryo transfer is about 7 mm at the end of natural or medically inducedfollicular phase
Whichconditions need this treatment?
Poorendometrial thickness is the most common reasons for infertility .Constantlythin endometrium having thickness below 7 mm because of followingconditions.
•Low levels of Estrogen hormone
•Traumato the uterus (cesarean sections, repetitive curettage),
•Previousanti- tumoral treatments (radiotherapy, chemotherapy, surgery)
∙Asherman's syndrome,( formation of adhesions (scar tissues) inside theendometrial cavity either post D&C or because of pelvic infections.)
•Chronic infections (Endometritis, Pelvic Inflammatory Disease)
•Conditions which cause inadequate blood flow (stress, malposition of uterus,fibrosis), • Clomiphene citrate -(a drug used for ovarian stimulation) if usedexcessively • Patients with low estradiol values
•Post hysteroscopic surgeries done for removal of polyps, fibroids &adhesions - mainly because of excessive use of electric cautery.
•Chronic Endometritis, polyps, endometrial hypoplasia,
•Uterine synechiae .
Whocan have the benefit of this treatment?
•Women who have experienced several failed IVF programs because of the uterinefactor.
•Women who are diagnosed with Asherman´s syndrome.
•Women who are diagnosed with female infertility caused by uterine hypoplasiaTreatment plans done for Endometrial Rejuvenation
-Severaltreatments are proposed over the years to enhance the endometrial thickening.Platelet Rich Plasma (PRP) has effect on endometrial cell proliferation, PRPincreases proliferation not only on fibroblasts but also on mesenchymalcells, which are progenitors of various types of cells, includingendometrial cells. Fresh whole blood collected from the same person is used toprepare Platelet Rich Plasma (PRP) also called autologous PRP, which isprocessed to separate platelets from the other blood Components. Infusionof PRP into the uterus is seen to improve endometrial growth andimplantation. Since autologous blood is used for PRP concerns regardingimmunogenic reactions and disease transmission is eliminated.Patientsconsidered for a PRP application must undergo hematological evaluation(blood tests) to exclude blood disorders or plateletdysfunction.Bone Marrow Mesenchymal Stem Cells (BM-MSCs) provide an alternatesource for regenerating the endometrium and repairing endometrial injuryaccording to the recent studies.
-Supplements of Estrogen & Progesterone hormones.
-Granulocytecolony stimulating Factor (GCSF), a protein which stimulates bone marrow isinfused into the uterus to produce more blood. Pretty effective, as it’sdirectly infused into uterus, the part which needs blood.
-Sub Cutaneous infusion of GCSF – the same as above, but instead of infusinginto uterus, its injected in skin. It should be given in regulatedquantity, because if an excessive amount of White Blood Cells (WBC) arepulled in reproductive organs, there might not be enough left in body tofight the infection.
-Vasoactive medicines like aspirin, vitamin E, l-arginine, sildenafil. These activatethe blood vessels to extend flow towards uterus, endometrium.
-Intrauterine infusion of Platlet Rich Plasma during which patient’s own plasmais extracted from her body, enriched with platelets then infused back touterus.
-A new research giving good results in improvement of Endometrial Thickness isperivascular stem cell therapy. It can generate endometrial cells. Howeverits still in research stage.
-Hysteroscopy is done for diagnosis of endometrial infection, removal offibroids, polyps, adhesions to enhance the endometrial surface quality& then Endometrial Rejuvenation Programme is started till the timeeffective results are achieved.
-To avoid post-surgical adhesions & improvement of cell growth inendometrial tissue, Intra-Uterine Contraceptive Device (IUCD) is kept infew cases.
-Associated treatment to enhance blood supply of Endometrium includeacupuncture, stress management, Exercise, Nutrition plan, yoga, Fertility message, castor oil packs.
Successfactors
EndometrialRejuvenation Treatment is successful if:
1- Endometrial Thickness above 9 mm with good blood supply is formed aftertreatment. 2 - There is Sub-endometrial blood supply up to Zone 4( thezone which is closest to the embryo).
Doctorsand biotechnologists have developed an innovative and extremely effectivetreatment to resolve the problem of poor endometrial health. EndometrialRejuvenation Treatment helps successful embryo implantation. The pregnancyis achieved through Natural Fertilization, and if that doesn't work IVF and IUI is done. Endometrial regeneration provides a truealternative to surrogacy for ladies who suffer from infertility because of uterine factors – who struggle with conditionslike Asherman's syndrome, endometrial hypoplasia, uterine synechiae andpoor endometrial thickness.
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