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How Topical Formulation Development in the Pharmaceutical Industry is Booming
Topical formulation development in the pharmaceutical industry is becoming increasingly famous. Skin acts as an ideal testing site for the drug delivery substances for both systemic and local impacts.

Topical formulation development in the pharmaceutical industry is becoming increasingly famous. Skin acts as an ideal testing site for the drug delivery substances for both systemic and local impacts. However, skin also performs as one type of mechanical barrier for the different types of drug penetration. Topical drug delivery comes with numerous advantages like 

  • The capability of delivering a drug substance more dedicatedly to a particular site
  • Ignoring the drug level fluctuations
  • Variations in the intra and inter-patient
  • Enhanced compliance
  • Improved self-medication substantiality

But all of the above advantages are dependent on including the perfect formulation of the drug. A tiny alteration in the topical formulation will have a massive difference in the efficiency of the disease treatments. In these tropical therapies, the formulation of the drug is as vital as the molecule present in it. It is due to the skin interaction that will alter the penetrated molecule's affectivity. 

The topical formulation development ensures the drug gets delivered to the correct site and is maintaining the dosage integrity, active duration, and proper drug transport. Additionally, a slight change in the formulation component properties like viscosity, oil and water amount, pH, stabilizers, surfactants, ionic nature, and droplet size can also influence the skin's efficacy and absorption. The selection of the correct recipients for the effective topical formulation development is exceptionally significant. The reaction of the drug with the recipient skin will alter the following.

  • Skin permeation capability
  • Shelf life stability
  • Non-metabolization in the skin
  • Ability to achieve the desired releasing rates
  • Staying dissolved capabilities at correct concentrations

Thus it is necessary to have a perfect and correct proportionate formulation of the topical development and select the excipients. It might include permeation and stabilizer enhancers, toxicological studies of tissues or cell lines, skin and IVRT studies, and ultimately the formulation development and optimization. Getting the formulation perfect will save a lot of time and money.